International Research Journal of Education and Technology

The present worked aimed at preparing transdermal patches of a combination of Pitavastatin and Ezetimibe to enhance the systemic absorption of both these drugs. Pitavastatin and Ezetimibe transdermal patches formulated with PEG-400 as plasticizer and polymers HPMC and ethyl cellulose by solvent evaporation method are quite stable. The weight variation of the patches was found to be between 1.032±0.092 gm to 0.917±0.085 gm. Thickness of the patches ranged from 0.27±0.04 mm to 0.18±0.05 mm and folding endurance was found between 137±49.10 to 510.25±49.10. The results reflect the ability of patches to withstand rupture satisfactorily. The drug in transdermal patches formulated ranged between 97.15 ± 3.36 to 88.64 ± 3.01% and 98.16 ± 6.95 to 82.49 ± 7.81% for Ezetimibe and Pitavastatin respectively. The low coefficient variation value indicates the uniformity of drug content in all formulations. The combination of HPMC and ethyl cellulose had enhanced diffusion rate.

Keywords

Transdermal, Patch, Pitavastatin, Ezetimibe, lipid lowering