International Research Journal of Education and Technology

ilver sulfadiazine has been used in the treatment of wounds associated with burns since ages due to its strong antiseptic properties. However, the penetration of drug from the conventional gel and cream formulations was not so high. With advent of nanotechnology, it has become possible to size down the metallic silver for better wound penetration and hence better efficacy. This study aims at functionalization of Silver nanoparticles synthesised by green synthesis employing aqueous leaf extract of Aegle marmelos and silver nitrate with sulfadiazine. So that the drug becomes ecologically safer as no or minimal drug has been used in the whole process. Silver nanoparticles has been prepared by reducing 1mM of Silver nitrate solution with Bael extract in the ratio of 1:10 and conforming the formation of silver nanoparticles using Surface plasmon resonance(SPR) from UV spectroscopy. The conjugation of silver sulfadiazine with silver nanoparticles was done in the ratio of 1:1. The particle size of Silver nanoparticles and silver sulfadiazine was found to be 149 nm and 132 nm respectively, however TEM images showed particle size within 100nm for Silver nanoparticles and within 70nm of Silver sulfadiazine. Zone of inhibition was calculated in order to find the efficacy of prepared conjugate against Bacillus subtillis, Escherichia coli and Aspergillus niger. Further characterisations PXRD, DSC, FTIR, Zeta Potential, ¹H and ¹³C NMR was done in order to confirm the conjugation, stability, and to determine their physicochemical properties. It was found from all the observations that Silver Sulfadiazine complex was formed and could be used in future through its administration from multiple dosage forms.

Keywords: Sulfadiazine, nanoparticles, Surface Plasmon Resonance, Zone of inhibition