International Research Journal of Education and Technology

In recent years, nanoparticle-based drug delivery systems have emerged as promising platforms for targeted therapy, offering the potential to enhance drug efficacy while minimizing off-target effects. Surface modification is a critical aspect of optimizing nanoparticle performance for specific therapeutic applications. Click chemistry, characterized by its modularity, selectivity, and high efficiency, has gained traction as a versatile tool for nanoparticle surface engineering. This review provides a comprehensive overview of recent advancements in click chemistry aimed at tailoring nanoparticle surfaces to improve targeted drug delivery. Key topics covered include the types of click reactions utilized, strategies for nanoparticle functionalization, and their applications in targeted drug delivery. Additionally, this review addresses current challenges in click chemistry-mediated nanoparticle surface modification, such as scalability, reproducibility, and biocompatibility, and discusses potential future directions for research in this rapidly evolving field. By elucidating the latest developments and outlining future prospects, this review aims to contribute to the continued advancement of nanoparticle-based drug delivery systems towards clinical translation and therapeutic innovation.

Keywords: Click Chemistry, Drug Efficacy, Targeted Therapy, Nanoparticle Functionalization, Cuaac Reaction, In Situ Functionalization