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| The Potential Use of Glucosinolates in Oral Cancer Therapy: A Comprehensive Review |
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Author Name Shouvik Das and Srinjoy Chatterjee Abstract Oral cancer is a significant global health burden, and current treatment modalities often entail side effects and limited efficacy. Hence, there is a growing interest in exploring natural compounds with potential anticancer properties as alternative or complementary therapies. Glucosinolates, found abundantly in cruciferous vegetables, have shown promising bioactive metabolites with demonstrated anticancer effects in various malignancies. This comprehensive review aims to explore the potential use of glucosinolates in oral cancer therapy, synthesizing existing evidence from in vitro studies and clinical trials. The review looks into the mechanisms of action underlying the potential anticancer properties of glucosinolates and their metabolites. Isothiocyanates, the major bioactive derivatives of glucosinolates, have been found to induce apoptosis, cell cycle arrest, and inhibit tumour growth in oral cancer cell lines and animal models. The modulation of key signalling pathways and the inhibition of angiogenesis and metastasis by glucosinolates, have been reported. Moreover, in vitro studies have highlighted the synergistic effects of glucosinolates with conventional chemotherapeutic agents, providing a basis for combination therapies. The comprehensive review presents a compelling body of evidence supporting the potential use of glucosinolates in oral cancer therapy. The growing interest in natural compounds as therapeutic agents, glucosinolates hold promise as a valuable addition to the collection of oral cancer treatment options. However, further research, including well-designed clinical trials, is needed to establish their safety, efficacy, and optimal dosages in the clinical setting.
Keywords– Glucosinolates, Oral Cancer, Phenethyl isothiocyanate, Cruciferous vegetables Published On : 2023-09-02 Article Download : 
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